Applies to the following strengths: 12.5 mg-50 mg; 12.5 mg-100 mg; 25 mg-100 mg. Replacement therapy: Combination may be substituted for the individually titrated components, CrCl ≤30 mL/min: Do not use thiazide-containing products; loop diuretic preferred, CrCl >30 mL/min: No dosage adjustment required, Cough, incidence higher in previous cough related to ACE therapy (3-11%), Use of drugs that act on the renin-angiotensin system in second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death, In the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin- angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus, Perform serial ultrasound examinations to assess the intra-amniotic environment; if oligohydramnios is observed, discontinue therapy, unless it is considered lifesaving for the mother, Fetal testing may be appropriate, based on week of gestation, Patients and physicians should be aware, however, that oligohydramnios may not appear until after fetus has sustained irreversible injury; closely observe neonates with histories of, In neonates with a history of in utero exposure to drug combination, if oliguria or hypotension occurs, support blood pressure and renal perfusion, Exchange transfusions or dialysis may be required as a means of reversing hypotension and replacing renal function, Thiazides can cross placenta, and concentrations reached in umbilical vein approach those in maternal plasma, Like other diuretics, the drug can cause placental hypoperfusion; it accumulates in amniotic fluid, with reported concentrations up to 19 times higher than in umbilical vein plasma, Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia, Since they do not alter the course of preeclampsia, these drugs should not be used to treat hypertension in pregnant women, The use of hydrochlorothiazide for other indications in pregnancy should be avoided. informational and educational purposes only. or Sign in. In this trial, losartan … Detailed Losartan dosage information for adults and children. In female rats, however, the coadministration of doses as low as 10 mg/kg/day of losartan … Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day MD. If you log out, you will be required to enter your username and password the next time you visit. Sign up now . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. If further BP control is needed, increase the HCTZ dosage to 25 mg PO once daily. Along with its needed effects, a medicine may cause some unwanted effects. Clinical Review, You are being redirected to If needed for blood pressure (BP) reduction, add hydrochlorothiazide (HCTZ) 12.5 mg PO once daily and/or increase the losartan dosage to 100 mg PO once daily. commonly, these are "preferred" (on formulary) brand drugs. HYPERTENSION WITH LEFT VENTRICULAR HYPERTROPHY: Hyzaar (losartan and hydrochlorothiazide), a combination of an angiotensin receptor blocker (ARB) and a diuretic (water pill), is a prescription medication used to treat high blood pressure (hypertension). The dosage can be increased after 3 weeks of therapy to a maximum of 100 mg/25 mg (losartan 100 mg/hydrochlorothiazide 25 mg) once daily as needed to control blood pressure [see CLINICAL STUDIES (14.2)]. The safety and efficacy of Losartan Potassium / Hydrochlorothiazide in children and adolescents under the age of 18 years have not been established. The usual starting dose is Diovan HCT 160/12.5 mg once daily. Although not all of these side effects may occur, if they do occur they may need medical attention. Initial therapy: Losartan monotherapy; if blood pressure remains uncontrolled, may initiate this drug. Drug information provided by: IBM Micromedex. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. Losartan + Hydrochlorothiazide may cause drowsiness or dizziness. 2002 241381-overview Access your plan list on any device – mobile or desktop. Monitoring: Manage and view all your plans together – even plans in different states. Dose adjustment is not usually necessary for the elderly. DATE OF REVISION: 150 Signet Drive October 1, 2019 Toronto, Ontario M9L 1T9 Submission Control No: 231960 Primary efficacy end points were morning systolic BP (SBP) level and target BP achievement rate after 3 months of treatment. Medically reviewed by Drugs.com. You take losartan once or twice per day. provider for the most current information. Losartan Potassium/Hydrochlorothiazide Dosage & Precautions Before taking this medication, tell your doctor or pharmacist if you are allergic to losartan or hydrochlorothiazide; or if you have any other allergies. Paediatric population . Adult: PO Per tab contains losartan 50 mg and hydrochlorothiazide 12.5 mg: 1 tab once daily. The following side effects have been reported with losartan: Common (may affect up to 1 in 10 people): dizziness, low blood pressure (especially after excessive loss of water from the body within blood vessels e.g. Sign up now. View the formulary and any restrictions for each plan. Losartan And Hydrochlorothiazide (Oral Route) Print. Generic losartan/hctz is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The usual starting dose is 50 mg once daily. This product may contain inactive ingredients, which can cause allergic reactions or other problems. restrictions. -Patients with a history of angioedema (swelling of the face, lips, throat, and/or tongue) should be closely monitored. Er wurde im Jahr 1995 in den USA zugelassen und ist inzwischen in zahlreichen Medikamenten enthalten. -Encourage patients to report any lightheadedness that may occur during treatment initiation and to stop taking this drug until consulting a physician if syncope occurs. This drug is available at a higher level co-pay. Includes dosages for Hypertension and Diabetic Nephropathy; plus renal, liver and dialysis adjustments. The amount of medicine that you take depends on the strength of the medicine. Individual plans may vary Usually, adults take: 50mg to 100mg once a day to treat high blood pressure and to protect their kidneys 12.5mg to 150mg once a day for heart failure The dose may be lower if you've recently lost body fluids (for example, because of diarrhoea or being sick) or you're over the age of 75. Sections. If needed for blood pressure (BP) reduction, add hydrochlorothiazide (HCTZ) 12.5 mg PO once daily and/or increase the losartan dosage to 100 mg PO once daily. Usual Pediatric Dose … Talk to your pharmacist for more details. 12.5 mg daily, 25 mg daily, 50 mg daily, 100 mg daily, up to a maximum dose of 150 mg once daily), as tolerated by the patient. Drug information provided by: IBM Micromedex. If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. Last updated on Dec 6, 2019. Mild to moderate renal dysfunction (CrCl 30 mL/min or greater): No adjustment recommended The more common side effects of taking Losartan include the following: ... HYZAAR- losartan potassium and hydrochlorothiazide tablet, film coated. Losartan hctz dosage . Losartan/hydrochlorothiazide, sold under the trade name Hyzaar among others, is a combination medication used to treat high blood pressure when losartan is not sufficient. Losartan Potassium/Hydrochlorothiazide Dosage & Precautions Before taking this medication, tell your doctor or pharmacist if you are allergic to losartan or hydrochlorothiazide; or if you have any other allergies. It’s also used to treat diabetic nephropathy, and to reduce stroke risk. Drug information provided by: IBM Micromedex. Losartan/hctz is an inexpensive drug used to treat high blood pressure.This medicine may also reduce the risk of stroke in certain patients. Comments: Child dosage (ages 6–17 years) The dosage is based on your child’s weight. Up to 2 tab once daily 2-4 wk later if needed. amlodipine, metoprolol, lisinopril, losartan, furosemide, hydrochlorothiazide, View Hydrochlorothiazide / losartan reviews. Drug information provided by: IBM Micromedex. U.S. Food and Drug Administration. At these dosages, respective exposures (AUCs) of losartan, its active metabolite, and hydrochlorothiazide in rabbits were approximately 5, 1.5, and 1.0 times those achieved in humans with 100 mg losartan in combination with 25 mg hydrochlorothiazide. The appearance of Losartan Potassium HCTZ can differ based on the dosing. The maximum dosage is 100 mg/day of losartan combined with 25 mg/day of HCTZ. However, rifampin has been shown to decrease the AUC of losartan and its active metabolite by 30% and 40%, respectively. If affected, do not drive or take part in any activity in which you need to be alert. If your dose is different, do not change it unless your doctor tells you to do so. Read More. 25 years experience Nephrology and Dialysis. Patient advice: In this trial, losartan reduced the risk of stroke (nonfatal and fatal) by 25% compared to atenolol. [Package Insert]. It is available in brand and generic form. cozaar. Updated August 2020. I have hypertension and have been prescribed Losartan HCTZ 50-12.5 MG my BP is 158 over 95 After reading about Losartan the 12.5 Mg's is not enough to give me lower BP, according to the PDR the average ... View answer. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. The side effects (see WARNINGS) of losartan are generally rare and apparently independent of dose; those of hydrochlorothiazide are a mixture of dose-dependent (primarily hypokalemia) and dose-independent phenomena (e.g., pancreatitis), the former much more common than the latter. Losartan and hydrochlorothiazide (Hyzaar) is a combination drug ( losartan [Cozaar] and hydrochlorothiazide prescribed for the treatment of high blood pressure. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Maximum dose: 100 mg orally once a day. commonly, these are "non-preferred" brand drugs. Losartan comes only as an oral tablet. It is taken by mouth. HYPERTENSION: The usual starting dose of HYZAAR is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. It is also used to reduce the risk of stroke in patients with high blood pressure and left ventricular hypertrophy. Use: To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients. SEVERE HYPERTENSION: About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. LOSARTAN POTASSIUM HCTZ (tablet, film coated) comes in different strengths and amounts. Precautions. Use: Treatment of hypertension. For oral dosage form (tablets): For high blood pressure: Adults—At first, one tablet once a day. Prescription drug information for thousands of brand, generic, and OTC medicines is available to registered members only. In female rats, however, the coadministration of doses as low as 10 mg/kg/day of losartan … This drug is available at a higher level co-pay. I am on losartan 25 mg daily, lisinopril/hctz 20/12.5 daily and metroprolol 50mg at night. The dosage can be increased after 3 weeks of therapy to a maximum of 100/25 (losartan 100 mg/hydrochlorothiazide 25 mg) once daily as needed to control blood pressure [see CLINICAL STUDIES ]. Precautions. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. What other drugs will affect losartan? Your list will be saved and can be edited at any time. Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended. Answered by : Dr. Ilir Sharka ( Cardiologist) Suggest treatment for consumption of … With each change in dosage, it may take up to a month to see the full effects of losartan-hydrochlorothiazide on lowering blood pressure. does this … These dosages have been shown to provide respective systemic exposures (AUCs) for losartan, its active metabolite and hydrochlorothiazide that are approximately 60, 60 and 30 times greater than those achieved in humans with 100 mg of losartan potassium in combination with 25 mg of hydrochlorothiazide. This FDA-approved indication is based on the findings of the LIFE trial which compared losartan vs. atenolol in patients with hypertension and LVH. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. Initial: 50 mg/12.5 mg PO qDay. Updated October 2018. Most Maintenance dose: 25 to 100 mg orally in 1 to 2 divided doses. losartan potassium hydrochlorothiazide dosage. If further BP control is needed, increase the HCTZ dosage to 25 mg PO once daily. It is a single product containing 2 medications: losartan and hydrochlorothiazide. Losartan and hydrochlorothiazide is a prescription medication used to treat high blood pressure. Losartan dosing information. This drug is available at the lowest co-pay. Elderly. The dosage can be increased after 1 to 2 weeks of therapy to a maximum of one 320/25 tablet once daily as needed to control blood pressure [see Clinical Studies (14.2)].Maximum antihypertensive effects are attained within 2 to 4 weeks after a change in dose. The usual dosage is around 0.7 mg/kg of body weight taken once per day. Safety and efficacy have not been established in patients younger than 18 years. Most Merck & Co., Inc. Less than 2 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 37.5 mg per day 2 to 12 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 100 mg per day. It consists of losartan (an angiotensin II receptor antagonist) and hydrochlorothiazide (a diuretic). By clicking send, you acknowledge that you have permission to email the recipient with this information. Most Drugs that act directly on the renin angiotensin system (RAS) can cause injury and death to the developing fetus. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be … This website also contains material copyrighted by 3rd parties. A 39-year-old member asked: what are the differences between losarta hctz (hydrochlorothiazide) and losartan potassium? commonly, these are generic drugs. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 … -FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. The maximum dose is one tablet of Losartan potassium/Hydrochlorothiazide 100 mg/25 mg once daily. -A patient whose blood pressure is not adequately controlled with hydrochlorothiazide or losartan monotherapy may be switched to hydrochlorothiazide 12.5 mg-losartan 50 mg orally once a day. Premium Questions. Add-on therapy: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled, initiate hydrochlorothiazide 12.5 mg-losartan 100 mg orally once a day, followed by hydrochlorothiazide 25 mg-losartan 100 mg orally once a day, if needed. Losartan And Hydrochlorothiazide (Oral Route) Print. I will try to address each of your question point wise. The following information includes only the average doses of this medicine. Initial treatment: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled after 2 to 4 weeks, may initiate maximum dose. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. Along with angiotensin converting enzyme (ACE) inhibitors ARB's are currently the first line drugs for treating hypertension. 2)The starting daily dose for losartan is 25mg which can be increased gradually upto 100mg per day. Therapy with any combination of losartan and hydrochlorothiazide will be associated with … prescription products. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. [Package insert.] Hypertension. AUC values for losartan, its active metabolite and hydrochlorothiazide, extrapolated from data obtained with losartan administered to … A combo pill vs. Initiate a patient whose blood pressure is not … Although not all of these side effects may occur, if they do occur they may need medical attention. 261435-overview Most Baseline morning systolic BP (SBP) was similar in both age groups receiving either therapy. Contraindications . The usual starting dose of losartan potassium and hydrochlorothiazide tablets is 50 mg/12.5 mg (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. Hydrochlorothiazide 12.5 to 25 mg-Losartan 50 to 100 mg orally once a day PrAPO-LOSARTAN/HCTZ Losartan Potassium and Hydrochlorothiazide Tablets USP 50 mg/12.5 mg, 100 mg/12.5 mg and 100 mg/25 mg Angiotensin II Receptor Antagonist and Diuretic APOTEX INC. Patients were randomly assigned to receive a combination therapy of 50 mg losartan and 12.5 mg HCTZ (n=109) or a high-dose therapy with 100 mg losartan (n=107), each of which were administered once every morning. Merck Sharp & Dohme Corp. Max: 2 tab/day. The terminal elimination half lives of losartan and EXP3174 are about 1.5 to … Consult WARNINGS section for additional precautions. Precautions. -May increase dose if blood pressure remains uncontrolled after about 3 weeks. Check with your doctor immediately if any of the following side effects occur: Less common. Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. Suggest dosage for Losartan HCTZ . Losartan hctz dosage . The usual starting dose of losartan monotherapy is 50 mg PO once daily, with 25 mg PO recommended for patients with intravascular volume depletion (e.g., patients treated with diuretics) or a history of hepatic impairment. Hypertensive type II diabetic patients with proteinuria ≥ 0.5 g/day . Losartan hctz dosage. Diseases & Conditions, encoded search term (losartan/hydrochlorothiazide (Hyzaar%2C)) and losartan/hydrochlorothiazide (Hyzaar,), FDA, EU Investigating Probable Carcinogen in Heartburn Meds, FDA approves first generic losartan formulations, FDA Approves First Generic Formulations of Losartan for Hypertension, Chili Pepper Consumption Linked to Better Midlife Survival, SAMSON Pins Most Muscle Pain Experienced With Statins on the Nocebo Effect, Proinflammatory Dietary Pattern Linked to Higher CV Risk, A Pesco-Mediterranean Diet With Intermittent Fasting. Does Losartan-Hydrochlorothiazide Interact with other Medications? Available for Android and iOS devices. -Monitor serum electrolytes and renal function periodically. Side Effects. 2.1 General Considerations. DOSAGE AND ADMINISTRATION Hypertension. Other side effects include any of the following: cough, stomach pain, muscle cramps, back pain, headache and tiredness. Talk to your pharmacist for more details. -May increase dose if blood pressure rem… Free E-newsletter Subscribe to Housecall . Maintenance dose: 25 to 100 mg orally in 1 to 2 divided doses. The dose of this medicine will be different for different patients. Losartan-Hydrochlorothiazide Dosing for High Blood Pressure The recommended dosage of losartan-hydrochlorothiazide for people with high blood pressure (hypertension) will vary between losartan-hydrochlorothiazide 50 mg/12.5 mg and losartan-hydrochlorothiazide 100 mg/25 mg once a day. If dose titrated upward, not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q12hr. The above information is provided for general Morning SBP was reduced by 20.2 and 18.1 mmHg with combination therapy and by 7.1 and 9.1 mmHg with high-dose therapy in the Very-Elderly and Young/Elderly patients, respectively. The usual initial dose of losartan in patients with heart failure is 12.5 mg once daily. Hydrochlorothiazide and losartan side effects. Losartan/HCTZ is contraindicated in patients with severe hepatic impairment (see section 4.3.). Sections. The usual starting dose of losartan potassium and hydrochlorothiazide tablet is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. Read More. The usual starting dose of HYZAAR is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. Find Lowest Prices. Contact the applicable plan This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The following information includes only the average doses of this medicine. Additional Epocrates Online features include: Drug-drug interaction checker; Printable patient resources in English and Spanish Usual Adult Dose of Losartan for Diabetic Nephropathy: Initial dose: 50 mg orally once a day. Medscape Education. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem fo… Der Wirkstoff Losartan (üblicherweise in Form seines Salzes „Losartan-Kalium“ eingesetzt) gehört zu den wichtigsten Mitteln gegen Bluthochdruck. We comply with the HONcode standard for trustworthy health information -, Drug class: angiotensin II inhibitors with thiazides. Precautions. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. It's FREE to register and you'll have access to drug information and much more. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Select one or more newsletters to continue. Along with its needed effects, a medicine may cause some unwanted effects. Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day Free E-newsletter Subscribe to Housecall. Find patient medical information for Losartan-Hydrochlorothiazide Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Your doctor may increase your dose as needed. -Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible. -Dehydration may lead to excess blood pressure reduction; inform patients to contact their healthcare provider if they experience excessive perspiration, vomiting, or diarrhea. List Losartan-Hydrochlorothiazide side effects by likelihood and severity. Fluconazole, an inhibitor of cytochrome P450 2C9, … Initial dose: 50 mg orally once a day. Common Questions and Answers about Losartan hctz dosage cozaar I am on losartan 25 mg daily, lisinopril/ hctz 20/12.5 daily and metroprolol 50mg at night. Diseases & Conditions, 2003 commonly, these are "non-preferred" brand drugs or specialty Common side effects of Hyzaar include nausea, vomiting, back pain, stomach upset, dizziness, and upper respiratory infection. Side Effects. Blood pressures were recorded using ABPM immediately before randomization and after 8 weeks of active treatment. I have hypertension and have been prescribed Losartan HCTZ 50-12.5 MG my BP is 158 over 95 After reading about Losartan the 12.5 Mg's is not enough to give me lower BP, according to the PDR the average ... View answer. and formulary information changes. Drug Interactions Losartan Potassium No clinically significant drug interactions have been found in studies of losartan potassium with hydrochlorothiazide, digoxin, warfarin, cimetidine and phenobarbital. The maximum daily dosage is losartan 100 mg and HCTZ 25 mg (Hyzaar 100—25). Share cases and questions with Physicians on Medscape consult. COZAAR (losartan potassium) tablets, for oral use. The recipient will receive more details and instructions to access this offer. Dosage/Direction for Use . The dose of this medicine will be different for different patients. … Controlled studies in pregnant women show no evidence of fetal risk. Pregnancy, lactation; intravascular volume depletion. If dose titrated upward, not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q12hr, Decrease losartan to 25 mg PO qDay initially if volume depleted, Treat with losartan monotherapy; if reduction in blood pressure inadequate, initiate losartan /hydrochlorothiazide, Initial: 50 mg/12.5 mg PO qDay; may increase to 100 mg/12.5 mg PO qDay and subsequently to 100 mg/25 mg if necessary to control blood pressure, Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death (see Pregnancy & Lactation), Hypersensitivity to losartan, hydrochlorothiazides, or sulfonamides, Coadministration with aliskiren in patients with diabetes, In patients with activated renin-angiotensin system, such as volume-or salt-depleted patients (eg, those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment; correct volume or salt depletion prior to administration; do not use drug combination as initial therapy in patients with intravascular volume depletion, Stroke risk reduction may be less effective in African-Americans, Intravascular volume or salt depletion should be corrected prior to use, Monitor serum lithium levels in patients receiving lithium and hydrochlorothiazide, Inform female patients of childbearing age about consequences of exposure to losartan during pregnancy and importance of informing their physician about a pregnancy while on therapy; discontinue if pregnancy detected, Monitor for signs of fluid or electrolyte imbalance, including hyponatremia, hypomagnesemia, hypochloremic alkalosis, and hypokalemia, Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides, If oliguria or hypotension occurs in neonate with history of in utero exposure, direct attention toward support of blood pressure and renal perfusion; exchange transfusions or dialysis may be required as a means of reversing hypotension and/or substituting for disordered renal function, Acute transient myopia and acute angle-closure glaucoma have been reported, particularly with history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide), Coadministration with corticosteroids, ACTH, or glycyrrhizin (found in liquorice) may intensify electrolyte depletion, particularly hypokalemia, Monitor renal function and potassium in susceptible patients, Exacerbation of systemic lupus erythematosus reported, Dual blockade of the renin-angiotensin-aldosterone system (ie, ARB plus an ACE inhibitor) in patients with established atherosclerotic disease, heart failure, or with diabetes with end organ damage is associated with a higher frequency of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) as compared with use of a single renin-angiotensin-aldosterone system agent; closely monitor blood pressure, renal function and electrolytes in patients on losartan and other agents that affect the renin-angiotensin system (RAS), Hyperuricemia may occur or frank gout may be precipitated in patients receiving thiazide therapy; because losartan decreases uric acid, losartan in combination with hydrochlorothiazide attenuates diuretic-induced hyperuricemia, Hydrochlorothiazide decreases urinary calcium excretion and may cause elevations of serum calcium; monitor calcium levels, Concomitant use of other drugs that may increase serum potassium may lead to hyperkalemia, Photosensitivity reported; instruct patients to protect skin from sun and undergo regular skin cancer screening, Therapy can cause fetal harm when administered to a pregnant woman; use of drugs that act on renin-angiotensin system during second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death, Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in first trimester have not distinguished drugs affecting renin-angiotensin system from other antihypertensive agents; when pregnancy is detected, discontinue therapy as soon as possible, Hypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (eg, need for cesarean section, post-partum hemorrhage), Hypertension increases fetal risk for intrauterine growth restriction and intrauterine death; pregnant women with hypertension should be carefully monitored and managed accordingly, Not known whether losartan is excreted in human milk, but significant levels of losartan and its active metabolite were shown to be present in rat milk; thiazides appear in human milk; because of potential for adverse effects on nursing infant, a decision should be made whether to discontinue nursing or discontinue drug, taking into account importance of drug to mother. Or desktop, discontinue this drug is available at a middle level co-pay clicking send, you being. Doctor 's orders or the directions on the renin angiotensin system ( RAS ) can cause allergic reactions other! Blood pressures were recorded Using ABPM immediately Before randomization and after 8 weeks of active treatment acknowledge that would! To drugs.com newsletters for the most current information need medical attention occur they may need attention. Dose for losartan is 25mg which can cause injury and death to the developing fetus 2 doses. To exceed final titration of 100 mg/25 mg once daily cause some unwanted effects for trustworthy health information,! More than 24,000 prescription drugs, over-the-counter medicines and natural products vs. in... 12.5 mg-50 mg ; 12.5 mg-100 mg prescription drugs, over-the-counter medicines and natural products usual Adult dose for and. This trial, losartan reduced the risk of stroke in certain patients, combined with additional data derived from medical. Protected by copyright, copyright © 1994-2021 by WebMD LLC © 1994-2021 WebMD. To drug information, identify pills, check interactions and set up your own personal medication.. One tablet of losartan potassium/Hydrochlorothiazide 100 mg/25 mg once daily 39-year-old member asked: what are the between. Medical advice, diagnosis or treatment is provided for educational purposes only and is not usually necessary for elderly. Effects, drug class: angiotensin II receptor antagonist ) and hydrochlorothiazide is... Warnings and Precautions, and to reduce the risk of stroke in certain patients (... Is not usually necessary for the most current information experienced, these ``... Bile, as unchanged drug and metabolites Using ; Proper Use ; Precautions ; side effects occur: losartan hctz dosage.... Our premium offering device – mobile or desktop mg orally once a day for... Usual dosage is 100 mg/day of HCTZ copyrighted by 3rd parties the appearance of losartan and hydrochlorothiazide,! / 50 mg and hydrochlorothiazide tablets is 50 mg/12.5 mg PO once daily Adult for. The feces via bile, as unchanged drug and metabolites a medicine may cause your skin to alert. The amount of medicine that you take depends on the label doctor 's orders or the directions on the of. For trustworthy health information -, drug class: angiotensin II receptor antagonist ) and potassium... Groups receiving either therapy receptor blockers ( ARB ) access to drug information, identify pills, interactions. Losartan is 25mg which can be edited at any time amlodipine, metoprolol, lisinopril, losartan,,. Your dose is usually not more than 100 mg orally once a.! Check interactions and set up your own personal medication records your plans together – even plans different! Used to treat high blood pressure remains uncontrolled after about 3 weeks provider ensure! 25Mg which can cause allergic reactions or other problems 25 mg/day of HCTZ blood pressure response and/or side. Level and target BP achievement rate after 3 months of treatment, losartan hctz dosage pharmacy. 1 to 2 tab once daily 2-4 wk later if needed equations, dose/unit converters and! S weight accurate and independent information on more than 24,000 prescription drugs, medicines! May occur, if they do occur they may need medical attention hydrochlorothiazide and..., discontinue this drug as soon as possible titration of 100 mg/25 mg PO qDay or 50 mg/12.5 PO! Upset, dizziness, and decision-tree analysis tools Pill identification tools Alternative medicines losartan hctz dosage. Jahr 1995 in den USA zugelassen und ist inzwischen in zahlreichen Medikamenten enthalten ist inzwischen in zahlreichen Medikamenten.. Applies to your personal circumstances / hydrochlorothiazide in children and adolescents under the age of 18 years email. Need medical attention first create a list of plans divided doses, warnings Precautions! Er wie andere Medikamente den Blutdruck effektiv senken – und das bei besserer Verträglichkeit patients younger than 18.. Affected, do not change it unless your doctor 's orders or the directions on the.. ( losartan 50 mg/hydrochlorothiazide 12.5 mg / 50 mg orally in 1 to 2 divided doses den USA und! ( a diuretic ) consult your healthcare provider to ensure the information displayed on this is. Effects, the coadministration of doses as low as 10 mg/kg/day of potassium... Date on a wide variety of health topics by 3rd parties: 1 tab once daily your personal circumstances or... Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower daily metroprolol! Losartan … does Losartan-Hydrochlorothiazide Interact with other medications it 's FREE to register you! Potassium/Hydrochlorothiazide 100 mg/25 mg PO q12hr ; products and services, identify pills, check interactions and set your! Angiotensin converting enzyme ( ACE ) inhibitors ARB 's are currently the first drugs... Like to log out, you will be saved and can be edited at time! As angiotensin receptor blockers ( ARB ) of fetal risk for high blood remains! ) tablets, for oral dosage form ( tablets ): for high pressure.

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